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Manipulating point defects for tailored macroscopic properties remains a formidable challenge in materials science. This study demonstrates a proof-of-principle for a universal law involving element Mn, significantly enhancing vacancy diffusion through an unprecedented anomalous Friedel Oscillations phenomenon, across most metals in the periodic table. The correlation between Mn-induced point-defect dynamic changes and intrinsic macro-properties is robustly validated through the first-principles theory and well-designed experiments. The physical origin stems from Mn's exceptionally large effective intra-elemental 3d electron interactions, surpassing the Coulomb attraction induced by vacancy and disrupting the electron screening effect. Given the ubiquitous nature of vacancies and their recognition as the most crucial defects influencing nearly all physical and mechanical properties of crystalline materials, this outcome may drive advances in a broad domain.