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Analytical study of the effect of recombination on evolution via DNA shuffling
Biological Physics · Submitted 28 Mar 2003
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population.
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The abstract, sentence by sentence
We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. | contribution 0.81 | 0.83 | 0.04 | asserted 0.98 |
| s1 | This model incorporates selection, recombination and point mutations. | method 0.96 | 0.42 | 0.03 | asserted 1.00 |
| s2 | The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. | contribution 0.65 | 0.92 | 0.11 | asserted 0.99 |
| s3 | We also briefly discuss finite population size corrections. | contribution 0.62 | 0.78 | 0.03 | asserted 0.57 |
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The paper
Original abstract
We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections.
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