HDRI is a six-principle eight-stage framework for hypothesis-organized LLM research featuring gap-driven iteration, traceable fact reasoning, and subject locking, realized in INFOMINER with reported gains in fact density and completeness.
Autodiscovery: Open-ended scientific discovery via bayesian surprise.arXiv preprint arXiv:2507.00310
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UG-TTT adds epistemic uncertainty measured by adapter disagreement as an exploration bonus in RL for LLMs, raising maximum reward and diversity on scientific discovery benchmarks.
Analogical reasoning increases LLM solution diversity by 90-173% and novelty rate to over 50%, delivering up to 13-fold gains on biomedical tasks including perturbation prediction and cell communication.
HypoExplore uses LLMs for hypothesis-driven evolutionary search with a Trajectory Tree and Hypothesis Memory Bank to discover lightweight vision architectures, reaching 94.11% accuracy on CIFAR-10 from an 18.91% baseline and generalizing to other datasets including state-of-the-art on MedMNIST.
citing papers explorer
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Hypothesis-Driven Deep Research with Large Language Models: A Structured Methodology for Automated Knowledge Discovery
HDRI is a six-principle eight-stage framework for hypothesis-organized LLM research featuring gap-driven iteration, traceable fact reasoning, and subject locking, realized in INFOMINER with reported gains in fact density and completeness.
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Epistemic Uncertainty for Test-Time Discovery
UG-TTT adds epistemic uncertainty measured by adapter disagreement as an exploration bonus in RL for LLMs, raising maximum reward and diversity on scientific discovery benchmarks.
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Unlocking LLM Creativity in Science through Analogical Reasoning
Analogical reasoning increases LLM solution diversity by 90-173% and novelty rate to over 50%, delivering up to 13-fold gains on biomedical tasks including perturbation prediction and cell communication.
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Agentic Discovery with Active Hypothesis Exploration for Visual Recognition
HypoExplore uses LLMs for hypothesis-driven evolutionary search with a Trajectory Tree and Hypothesis Memory Bank to discover lightweight vision architectures, reaching 94.11% accuracy on CIFAR-10 from an 18.91% baseline and generalizing to other datasets including state-of-the-art on MedMNIST.