Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating
classification
⚛️ physics.bio-ph
cond-mat.mes-hallcond-mat.soft
keywords
electron-conformationalheartunderablebeatingbiophysicallycellcells
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We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.
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