Recognition: unknown
Concept Inconsistency in Dermoscopic Concept Bottleneck Models: A Rough-Set Analysis of the Derm7pt Dataset
Pith reviewed 2026-05-10 02:17 UTC · model grok-4.3
The pith
Inconsistent concept profiles in Derm7pt impose a 92.1% accuracy ceiling on hard concept bottleneck models for melanoma detection.
A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.
Core claim
Among the 305 unique concept profiles formed by the 7 dermoscopic criteria of the 7-point melanoma checklist, 50 (16.4%) are inconsistent, spanning 306 images (30.3% of the dataset). This yields a theoretical accuracy ceiling of 92.1%, independent of backbone architecture or training strategy for CBMs that exclusively operate with hard concepts. Symmetric removal of all boundary-region images yields Derm7pt+, a fully consistent benchmark subset of 705 images with perfect quality of classification and no hard accuracy ceiling. Building on this filtered dataset, EfficientNet-B5 achieves the best label F1 score (0.85) and label accuracy (0.90) on the held-out test set under symmetric filtering,
What carries the argument
Rough-set analysis of the 305 concept profiles to detect inconsistencies where the same seven-criteria combination maps to both benign and malignant diagnoses.
If this is right
- CBMs using hard concepts on the full Derm7pt cannot exceed 92.1% accuracy due to the conflicting profiles.
- Symmetric removal of boundary images produces a 705-image consistent subset with no accuracy ceiling.
- On the filtered set, EfficientNet-B5 reaches 0.90 label accuracy and 0.70 concept accuracy under symmetric filtering.
- Asymmetric filtering allows EfficientNet-B7 to reach 0.82 label F1 and 0.70 concept accuracy.
Where Pith is reading between the lines
- Other medical imaging datasets that rely on multi-criteria concept labels may contain similar hidden inconsistencies that limit interpretable models.
- Annotation protocols could be improved by focusing extra review on the dermoscopic features that most frequently generate boundary conflicts.
- Replacing hard concept assignments with soft or probabilistic ones might allow models to surpass the 92.1% ceiling on the original data.
- The cleaned Derm7pt+ subset provides a reproducible testbed for comparing concept-based methods without data-quality confounds.
Load-bearing premise
The concept annotations supplied with Derm7pt are treated as accurate ground truth, making observed inconsistencies an intrinsic property of the clinical data.
What would settle it
Re-annotating the 306 images that belong to inconsistent profiles and finding zero remaining conflicts would show the inconsistencies were annotation artifacts rather than fixed properties of the dataset.
Figures
read the original abstract
Concept Bottleneck Models (CBMs) route predictions exclusively through a clinically grounded concept layer, binding interpretability to concept-label consistency. When a dataset contains concept-level inconsistencies, identical concept profiles mapped to conflicting diagnosis labels create an unresolvable bottleneck that imposes a hard ceiling on achievable accuracy. In this paper, we apply rough set theory to the Derm7pt dermoscopy benchmark and characterize the full extent and clinical structure of this inconsistency. Among 305 unique concept profiles formed by the 7 dermoscopic criteria of the 7-point melanoma checklist, 50 (16.4%) are inconsistent, spanning 306 images (30.3% of the dataset). This yields a theoretical accuracy ceiling of 92.1%, independent of backbone architecture or training strategy for CBMs that exclusively operate with hard concepts. In addition, we characterize the conflict-severity distribution, identify the clinical features most responsible for boundary ambiguity, and evaluate two filtering strategies with quantified effects on dataset composition and CBM interpretability. Symmetric removal of all boundary-region images yields Derm7pt+, a fully consistent benchmark subset of 705 images with perfect quality of classification and no hard accuracy ceiling. Building on this filtered dataset, we present a hard CBM evaluated across 19 backbone architectures from the EfficientNet, DenseNet, ResNet, and Wide ResNet families. Under symmetric filtering, explored for completeness, EfficientNet-B5 achieves the best label F1 score (0.85) and label accuracy (0.90) on the held-out test set, with a concept accuracy of 0.70. Under asymmetric filtering, EfficientNet-B7 leads across all four metrics, reaching a label F1 score of 0.82 and concept accuracy of 0.70. These results establish reproducible baselines for concept-consistent CBM evaluation on dermoscopic data.
Editorial analysis
A structured set of objections, weighed in public.
Referee Report
Summary. The paper applies rough-set theory to the Derm7pt dataset to quantify concept-level inconsistencies arising from the 7 dermoscopic criteria of the 7-point checklist. It reports that 50 of 305 unique concept profiles (16.4%) are inconsistent, spanning 306 images (30.3% of the data) and imposing a 92.1% theoretical accuracy ceiling on any hard-concept CBM, independent of backbone or training. The authors introduce symmetric and asymmetric filtering to produce the consistent Derm7pt+ subset (705 images), then evaluate hard CBMs across 19 architectures from EfficientNet, DenseNet, ResNet, and Wide ResNet families, with EfficientNet-B5 and B7 achieving the strongest label and concept metrics on the filtered data.
Significance. If the inconsistency counts and derived ceiling hold, the work identifies a concrete, data-intrinsic limit on CBM performance for this clinically relevant benchmark and supplies a cleaned, reproducible subset together with baselines across 19 architectures. The exhaustive enumeration of profiles, direct application of indiscernibility, and provision of parameter-free accuracy bounds are strengths that support falsifiable claims about interpretability bottlenecks in medical imaging.
minor comments (2)
- The abstract and results sections refer to 'symmetric removal of all boundary-region images' and 'symmetric filtering' without an explicit definition or pseudocode for how boundary regions are identified from the rough-set lower/upper approximations; this notation should be clarified with a short example or equation in the methods.
- Table or supplementary material listing the 50 inconsistent profiles (or at least the distribution of conflict severity) would strengthen verifiability of the 306-image count and 92.1% ceiling; currently the numbers are stated but not broken down by profile.
Simulated Author's Rebuttal
We thank the referee for the positive and accurate summary of our work, as well as the recommendation for minor revision. The assessment correctly identifies the core contributions: the rough-set enumeration of inconsistent concept profiles in Derm7pt, the resulting 92.1% accuracy ceiling for hard CBMs, and the provision of the consistent Derm7pt+ subset together with baselines across 19 architectures.
Circularity Check
No significant circularity detected
full rationale
The paper computes inconsistency counts and the accuracy ceiling by direct application of standard rough-set indiscernibility to the raw Derm7pt annotation table: identical 7-concept vectors are grouped, label conflicts within each group are tallied, and the ceiling is obtained from the per-group majority-vote bound. These steps use only the supplied data and the definition of inconsistency; no parameters are fitted, no equations are self-referential, and the claimed independence from backbone or training strategy follows logically from the hard-concept CBM premise. No load-bearing premise rests on self-citation chains or imported uniqueness theorems. The derivation is therefore self-contained against external benchmarks.
Axiom & Free-Parameter Ledger
axioms (1)
- standard math Rough set theory identifies inconsistent objects by comparing lower and upper approximations of decision classes.
Reference graph
Works this paper leans on
-
[1]
& Doshi-Velez, F
Havasi, M., Parbhoo, S. & Doshi-Velez, F. Addressing leakage in concept bottleneck models. InAdvances in Neural Information Processing Systems, vol. 35, 23386–23397 (2022)
2022
-
[2]
Promises and pitfalls of black-box concept learning models.arXiv preprint arXiv:2106.13314, 2021
Mahinpei, A., Clark, J., Lage, I., Doshi-Velez, F. & Pan, W. Promises and pitfalls of black-box concept learning models. InICML 2021 Workshop on Theoretic Foundation, Criticism, and Application Trend of Explainable AI, DOI: 10.48550/arXiv.2106.13314 (2021)
-
[3]
Shin, S., Jo, Y ., Ahn, S. & Lee, N. A closer look at the intervention procedure of concept bottleneck models. InProceedings of the 40th International Conference on Machine Learning, vol. 202 ofProceedings of Machine Learning Research, 31504–31520, DOI: 10.48550/arXiv.2302.14260 (PMLR, 2023)
-
[4]
InAdvances in Neural Information Processing Systems, vol
Espinosa Zarlenga, M.et al.Concept embedding models: Beyond the accuracy-explainability trade-off. InAdvances in Neural Information Processing Systems, vol. 35, 21400–21413, DOI: 10.48550/arXiv.2209.09056 (2022)
-
[5]
Post-hoc concept bottleneck models
Yuksekgonul, M., Wang, M. & Zou, J. Post-hoc concept bottleneck models. InThe Eleventh International Conference on Learning Representations, DOI: 10.48550/arXiv.2205.15480 (2023)
-
[6]
Oikarinen, T., Das, S., Nguyen, L. M. & Weng, T.-W. Label-free concept bottleneck models. InThe Eleventh International Conference on Learning Representations, DOI: 10.48550/arXiv.2304.06129 (2023)
-
[7]
Schrodi, S., Schur, J., Argus, M. & Brox, T. Concept bottleneck models without predefined concepts.Transactions on Mach. Learn. Res.(2025). 9.Ciravegna, G.et al.Logic explained networks.Artif. Intell.314, 103822, DOI: 10.1016/j.artint.2022.103822 (2023)
-
[8]
Esteva, A.et al.Dermatologist-level classification of skin cancer with deep neural networks.Nature542, 115–118, DOI: 10.1038/nature21056 (2017)
-
[9]
Hauser, K.et al.Explainable artificial intelligence in skin cancer recognition: A systematic review.Eur. J. Cancer167, 54–69, DOI: 10.1016/j.ejca.2022.02.025 (2022)
-
[10]
O’Connor, and Kevin McGuinness
Lucieri, A.et al.On interpretability of deep learning based skin lesion classifiers using concept activation vectors. In2020 International Joint Conference on Neural Networks (IJCNN), 1–10, DOI: 10.1109/IJCNN48605.2020.9206946 (2020)
-
[11]
Patrício, C., Neves, J. C. & Teixeira, L. F. Coherent concept-based explanations in medical image and its application to skin lesion diagnosis. InProceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW), 3798–3807, DOI: 10.1109/CVPRW59228.2023.10208381 (2023)
-
[12]
Patrício, C., Teixeira, L. F. & Neves, J. C. A two-step concept-based approach for enhanced interpretability and trust in skin lesion diagnosis.Comput. Struct. Biotechnol. J.28, 71–79, DOI: 10.1016/j.csbj.2025.02.013 (2025)
-
[13]
Commun.16, 4739, DOI: 10.1038/s41467-025-59532-5 (2025)
Chanda, T.et al.Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: Eye-tracking study.Nat. Commun.16, 4739, DOI: 10.1038/s41467-025-59532-5 (2025)
-
[14]
Mendonça, T., Ferreira, P. M., Marques, J. S., Marçal, A. R. S. & Rozeira, J. PH2 – a dermoscopic image database for research and benchmarking. In2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 5437–5440, DOI: 10.1109/EMBC.2013.6610779 (2013). 13/14
-
[15]
Scientific Data5(1), 180161 (Aug 2018)
Tschandl, P., Rosendahl, C. & Kittler, H. The HAM10000 dataset, a large collection of multi-source dermatoscopic images of common pigmented skin lesions.Sci. Data5, 180161, DOI: 10.1038/sdata.2018.161 (2018)
-
[16]
Data11, 641, DOI: 10.1038/ s41597-024-03387-w (2024)
Hernández-Pérez, C.et al.BCN20000: Dermoscopic lesions in the wild.Sci. Data11, 641, DOI: 10.1038/ s41597-024-03387-w (2024). 19.Combalia, M.et al.BCN20000: Dermoscopic lesions in the wild, DOI: 10.48550/arXiv.1908.02288 (2019)
-
[17]
Rotemberg, V .et al.A patient-centric dataset of images and metadata for identifying melanomas using clinical context. Sci. Data8, 34, DOI: 10.1038/s41597-021-00815-z (2021)
-
[18]
Yilmaz, A., Yasar, S. P., Gencoglan, G. & Temelkuran, B. DERM12345: A large, multisource dermatoscopic skin lesion dataset with 40 subclasses.Sci. Data11, 1302, DOI: 10.1038/s41597-024-04104-3 (2024)
-
[19]
IEEE Journal of Biomedical and Health Informatics23(2), 538–546 (Mar 2019)
Kawahara, J., Daneshvar, S., Argenziano, G. & Hamarneh, G. Seven-point checklist and skin lesion classification using multitask multimodal neural nets.IEEE J. Biomed. Heal. Informatics23, 538–546, DOI: 10.1109/JBHI.2018.2824327 (2019)
-
[20]
Saeed, M. A., Afify, Y . M., Badr, N. L. & Helal, N. A. Multimodal deep learning ensemble framework for skin cancer detection.Sci. Reports15, 45660, DOI: 10.1038/s41598-025-30534-z (2025). 24.Pawlak, Z. Rough sets.Int. J. Comput. Inf. Sci.11, 341–356, DOI: 10.1007/BF01001956 (1982)
-
[21]
Theory and Decision Library D (Springer, Dordrecht, 1991)
Pawlak, Z.Rough Sets: Theoretical Aspects of Reasoning about Data. Theory and Decision Library D (Springer, Dordrecht, 1991)
1991
-
[22]
& Sola, S
Massone, C., Hofman-Wellenhof, R., Chiodi, S. & Sola, S. Dermoscopic criteria, histopathological correlates and genetic findings of thin melanoma on non-volar skin.Genes12, 1288 (2021)
2021
-
[23]
Rodríguez-Lomba, E.et al.Concordance analysis of dermoscopic features between five observers in a sample of 200 dermoscopic images.Anais Brasileiros de Dermatol.97, 382–384 (2022)
2022
-
[24]
Wilson, E. B. Probable inference, the law of succession, and statistical inference.J. Am. Stat. Assoc.22, 209–212, DOI: 10.1080/01621459.1927.10502953 (1927)
-
[25]
Nápoles, G., Grau, I., Jastrzebska, A. & Salgueiro, Y . Presumably correct decision sets.Pattern Recognit.141, 1–35, DOI: 10.1016/j.patcog.2023.109640 (2023)
-
[26]
Hou, J., Xu, J. & Chen, H. Concept-attention whitening for interpretable skin lesion diagnosis. InMedical Image Computing and Computer Assisted Intervention – MICCAI 2024, vol. 15010 ofLecture Notes in Computer Science, 109–119, DOI: 10.1007/978-3-031-72117-5_11 (Springer, 2024)
-
[27]
Methods Programs Biomed.215, 106620, DOI: 10.1016/j.cmpb.2022.106620 (2022)
Lucieri, A.et al.ExAID: A multimodal explanation framework for computer-aided diagnosis of skin lesions.Comput. Methods Programs Biomed.215, 106620, DOI: 10.1016/j.cmpb.2022.106620 (2022)
-
[28]
Bie, Y ., Luo, L. & Chen, H. MICA: Towards explainable skin lesion diagnosis via multi-level image-concept alignment. In Proceedings of the AAAI Conference on Artificial Intelligence, 837–845, DOI: 10.1609/aaai.v38i2.27842 (2024)
-
[29]
Tan, M. & Le, Q. EfficientNet: Rethinking model scaling for convolutional neural networks. In Chaudhuri, K. & Salakhutdinov, R. (eds.)Proceedings of the 36th International Conference on Machine Learning, vol. 97 ofProceedings of Machine Learning Research, 6105–6114 (PMLR, 2019)
2019
-
[30]
& Weinberger, K
Huang, G., Liu, Z., van der Maaten, L. & Weinberger, K. Q. Densely connected convolutional networks. InProceedings of the IEEE Conference on Computer Vision and Pattern Recognition(2017)
2017
-
[31]
He, K., Zhang, X., Ren, S. & Sun, J. Deep residual learning for image recognition. InProceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR)(2016). 36.Zagoruyko, S. & Komodakis, N. Wide residual networks.CoRRabs/1605.07146(2016). 14/14
work page internal anchor Pith review arXiv 2016
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