Megahertz single-particle imaging at the European XFEL

Abbas Ourmazd; Adam Round; Adrian Mancuso; Ahmad Hosseinizadeh; Alessandro Silenzi; Andrei V. Rode; Anthon Teslyuk; Anton Barty; Benedikt J. Daurer; Brenda G. Hogue

Megahertz single-particle imaging at the European XFEL

Not yet reviewed by Pith; the record is open.

Re-run · record.json Download PDF Read on arXiv ↗

This paper has not been read by Pith yet. Machine review is queued; the pith claim, tier, and objections will appear here once it completes.

SPECIMEN: schema-true, not a live event

T0 review · schema-true

One-sentence machine reading of the paper's core claim.

pith:XXXXXXXX · record.json · timestamp

arxiv 1912.10796 v1 pith:BKNDHTPU submitted 2019-12-14 physics.ins-det physics.bio-ph

Megahertz single-particle imaging at the European XFEL

Egor Sobolev , Serguey Zolotarev , Klaus Giewekemeyer , Johan Bielecki , Kenta Okamoto , Hemanth K. N. Reddy , Jakob Andreasson , Kartik Ayyer

show 55 more authors

Imrich Barak Sadia Bari Anton Barty Richard Bean Sergey Bobkov Henry N. Chapman Grzegorz Chojnowski Benedikt J. Daurer Katerina D\"orner Tomas Ekeberg Leonie Fl\"uckiger Oxana Galzitskaya Luca Gelisio Steffen Hauf Brenda G. Hogue Daniel A. Horke Ahmad Hosseinizadeh Vyacheslav Ilyin Chulho Jung Chan Kim Yoonhee Kim Richard A. Kirian Henry Kirkwood Olena Kulyk Romain Letrun Duane Loh Marc Messerschmidt Kerstin M\"uhlig Abbas Ourmazd Natascha Raab Andrei V. Rode Max Rose Adam Round Takushi Sato Robin Schubert Peter Schwander Jonas A. Sellberg Marcin Sikorski Alessandro Silenzi Changyong Song John C. H. Spence Stephan Stern Jolanta Sztuk-Dambietz Anthon Teslyuk Nicusor Timneanu Martin Trebbin Charlotte Uetrecht Britta Weinhausen Garth J. Williams P Lourdu Xavier Chen Xu Ivan Vartanyants Victor Lamzin Adrian Mancuso Filipe R. N. C. Maia

This is my paper

classification physics.ins-det physics.bio-ph

keywords imagingsingle-particlex-rayraterepetitionxfeldiffractioneuropean

verification ladder T0 review T1 audit T2 compute T3 formal T4 reserved

0 comments

read the original abstract

The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL will soon provide 27,000 pulses per second, more than two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The obtained results pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.

discussion (0)

Forward citations

Cited by 1 Pith paper

Reviewed papers in the Pith corpus that reference this work. Sorted by Pith novelty score.

Controlled beams of cryo-cooled protein-like nanoparticles
physics.ins-det 2026-04 unverdicted novelty 4.0

A cryogenic buffer-gas-cell-aerodynamic-lens-stack generates controllable beams of shock-frozen protein-like nanoparticles, characterized using strong-field ionization and velocity-map imaging for flux and density det...