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Protein corona composition of PEGylated nanoparticles correlates strongly with amino acid composition of protein surface
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Protein corona composition of PEGylated nanoparticles correlates strongly with amino acid composition of protein surface
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Extensive molecular dynamics simulations reveal that the interactions between proteins and poly(ethylene glycol)(PEG) can be described in terms of the surface composition of the proteins. PEG molecules accumulate around non-polar residues while avoiding polar ones. A solvent-accessible-surface-area model of protein adsorption on PEGylated nanoparticles accurately fits a large set of data on the composition of the protein corona recently obtained by label-free proteomic mass spectrometry.
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