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Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL

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arxiv 2505.17952 v1 pith:PMI7K22Q submitted 2025-05-23 cs.CL cs.AI

Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL

classification cs.CL cs.AI
keywords reasoningbenchmarksmedicalminimalistmodelswithoutalphamedchallenging
verification ladder T0 review T1 audit T2 compute T3 formal T4 reserved
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Improving performance on complex tasks and enabling interpretable decision making in large language models (LLMs), especially for clinical applications, requires effective reasoning. Yet this remains challenging without supervised fine-tuning (SFT) on costly chain-of-thought (CoT) data distilled from closed-source models (e.g., GPT-4o). In this work, we present AlphaMed, the first medical LLM to show that reasoning capability can emerge purely through reinforcement learning (RL), using minimalist rule-based rewards on public multiple-choice QA datasets, without relying on SFT or distilled CoT data. AlphaMed achieves state-of-the-art results on six medical QA benchmarks, outperforming models trained with conventional SFT+RL pipelines. On challenging benchmarks (e.g., MedXpert), AlphaMed even surpasses larger or closed-source models such as DeepSeek-V3-671B and Claude-3.5-Sonnet. To understand the factors behind this success, we conduct a comprehensive data-centric analysis guided by three questions: (i) Can minimalist rule-based RL incentivize reasoning without distilled CoT supervision? (ii) How do dataset quantity and diversity impact reasoning? (iii) How does question difficulty shape the emergence and generalization of reasoning? Our findings show that dataset informativeness is a key driver of reasoning performance, and that minimalist RL on informative, multiple-choice QA data is effective at inducing reasoning without CoT supervision. We also observe divergent trends across benchmarks, underscoring limitations in current evaluation and the need for more challenging, reasoning-oriented medical QA benchmarks.

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Cited by 7 Pith papers

Reviewed papers in the Pith corpus that reference this work. Sorted by Pith novelty score.

  1. Credit Cards, Confusion, Computation, and Consequences: What Can We Uncover About Language Model Reasoning?

    cs.CL 2026-07 conditional novelty 6.5

    CreditCardQA shows LLMs err mainly on credit-card contractual conditions and comparisons, not arithmetic, with Program-of-Thought narrowing open–closed model gaps.

  2. CLR-voyance: Reinforcing Open-Ended Reasoning for Inpatient Clinical Decision Support with Outcome-Aware Rubrics

    cs.CL 2026-05 unverdicted novelty 6.0

    CLR-voyance reformulates inpatient reasoning as POMDP with clinician-validated outcome rubrics, yielding an 8B model that outperforms larger frontier models on the authors' new benchmark.

  3. AdaThink-Med: Optimizing Inference-Time Compute for Medical Reasoning via Uncertainty Quantification

    cs.CL 2025-09 conditional novelty 6.0

    An entropy-guided reward that shortens answers to easy, confident questions and extends reasoning on hard ones reduces medical QA tokens by 4.7x to 6.4x with minimal accuracy loss.

  4. Evo-MedAgent: Beyond One-Shot Diagnosis with Agents That Remember, Reflect, and Improve

    cs.AI 2026-04 unverdicted novelty 5.0

    Evo-MedAgent adds three evolving memory stores to LLM agents for chest X-ray diagnosis, raising MCQ accuracy from 0.68 to 0.79 on GPT-5-mini and 0.76 to 0.87 on Gemini-3 Flash without any training.

  5. Medical Reasoning with Large Language Models: A Survey and MR-Bench

    cs.CL 2026-03 accept novelty 5.0

    LLMs show strong exam performance on medical tasks but exhibit a clear gap in accuracy on authentic clinical decision-making as measured by the new MR-Bench benchmark and unified evaluations.

  6. InfiMed-ORBIT: Aligning LLMs on Open-Ended Complex Tasks via Rubric-Based Incremental Training

    cs.CL 2025-10 conditional novelty 5.0

    Rubric-based incremental RL with LLM-generated case-specific checklists lifts Qwen3-4B's HealthBench-Hard score from 7.0 to 27.5 with 2k samples, and improves InfoBench instruction-following from 42.0 to 82.9.

  7. UniReason-Med: A Shared Grounded Reasoning Interface for 2D-to-3D Transfer in Medical VQA

    cs.CV 2026-06 unverdicted novelty 4.0

    UniReason-Med introduces a unified framework for 2D and 3D medical VQA with shared grounded reasoning, trained on a 220K dataset, claiming that joint 2D+3D supervision improves 3D performance over 3D-only training.