Pith. sign in

REVIEW 6 cited by

Exploring Scaling Laws for EHR Foundation Models

Not yet reviewed by Pith; the record is open.

This paper has not been read by Pith yet. Machine review is queued; the pith claim, tier, and objections will appear here once it completes.

SPECIMEN: schema-true, not a live event

T0 review · schema-true

One-sentence machine reading of the paper's core claim.

pith:XXXXXXXX · record.json · timestamp

arxiv 2505.22964 v2 pith:EXDI54D5 submitted 2025-05-29 cs.CL cs.AIcs.LG

Exploring Scaling Laws for EHR Foundation Models

classification cs.CL cs.AIcs.LG
keywords modelsscalingcomputedatafoundationlawsmodelclinical
verification ladder T0 review T1 audit T2 compute T3 formal T4 reserved
0 comments
Share X LinkedIn Reddit HN
read the original abstract

The emergence of scaling laws has profoundly shaped the development of large language models (LLMs), enabling predictable performance gains through systematic increases in model size, dataset volume, and compute. Yet, these principles remain largely unexplored in the context of electronic health records (EHRs) -- a rich, sequential, and globally abundant data source that differs structurally from natural language. In this work, we present the first empirical investigation of scaling laws for EHR foundation models. By training transformer architectures on patient timeline data from the MIMIC-IV database across varying model sizes and compute budgets, we identify consistent scaling patterns, including parabolic IsoFLOPs curves and power-law relationships between compute, model parameters, data size, and clinical utility. These findings demonstrate that EHR models exhibit scaling behavior analogous to LLMs, offering predictive insights into resource-efficient training strategies. Our results lay the groundwork for developing powerful EHR foundation models capable of transforming clinical prediction tasks and advancing personalized healthcare.

discussion (0)

Sign in with ORCID, Apple, or X to comment. Anyone can read and Pith papers without signing in.

Forward citations

Cited by 6 Pith papers

Reviewed papers in the Pith corpus that reference this work. Sorted by Pith novelty score.

  1. On the Invariance and Generality of Neural Scaling Laws

    cs.LG 2026-05 unverdicted novelty 7.0

    Neural scaling laws are invariant under bijective data transformations and change predictably with information resolution ρ under non-bijective transformations, enabling cross-domain transport of fitted exponents.

  2. Pretraining EHR Foundation Models with Patient-Aware Sampling

    cs.LG 2026-07 conditional novelty 6.0

    Patient-aware sampling of pretraining windows, with patients weighted by a tunable exponent, improves downstream AUROC/AUPRC over a global token-stream baseline in autoregressive EHR models.

  3. Foundation Models to Unlock Real-World Evidence from Nationwide Medical Claims

    cs.AI 2026-05 unverdicted novelty 6.0

    A foundation model trained from scratch on nationwide medical claims data outperforms prior methods on over 1,000 disease prediction tasks and improves real-world evidence analyses.

  4. TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection

    cs.AI 2026-04 unverdicted novelty 6.0

    TrajOnco uses a chain-of-agents LLM architecture with memory to perform temporal reasoning on longitudinal EHR, achieving 0.64-0.80 AUROC for 1-year multi-cancer risk prediction in zero-shot mode on matched cohorts wh...

  5. Scaling Recurrence-aware Foundation Models for Clinical Records via Next-Visit Prediction

    cs.LG 2026-03 unverdicted novelty 6.0

    RAVEN pretrains on over one million EHR sequences via recurrence-aware next-visit event prediction, enabling zero-shot disease incidence forecasting that rivals fine-tuned models and generalizes across cohorts.

  6. Autoregressive EHR Foundation Models with Multimodal Inputs

    cs.LG 2026-07 conditional novelty 5.0

    Latent compression improves multimodal fusion, but ICU mortality predictions from EHR plus ECG, CXR, and notes are generally no better than EHR-only.