MedHal-Loc benchmark shows KG-triple hallucination detectors localize errors no better than chance on controlled medical statements due to entity extraction limits, while NLI and consistency methods succeed above chance, and real hallucinations are mostly diffuse conclusion changes.
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Large Language Models Encode Clinical Knowledge
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AutoMedBench evaluates AI agents on long-horizon medical workflows across five stages and finds validation and submission as dominant failure points based on thousands of runs.
MemPoison enables stealthy memory poisoning in LLM agents via dialogue by using semantic relational bridges, entity masquerading, and joint embedding optimization to bypass selective extraction and rewriting, achieving up to 0.95 attack success rate.
JMed48k is a new benchmark of Japanese healthcare licensing exams used to evaluate 21 VLMs, with a paired image-removal audit revealing large differences in how models and professions benefit from visual content.
A novel FMECA-based framework was developed and validated for systematic assessment of patient safety risks in LLM-generated clinical discharge summaries, demonstrating moderate-to-substantial inter-rater agreement and good usability.
A controlled four-LLM analyst pipeline over 68 commercial-compatible physiological corpora produced 94 build-now detector components after deduplication, threshold audit, and native-channel/no-personalization gates.
Cross-lingual prompt exploration improves factual recall and consistency in LLMs across 17 languages more efficiently than native-language scaling.
MARD-7B outperforms baselines and GPT-4o on novel drug pairs for mechanism-level DDI prediction via a new distillation pipeline with verifiable process rewards and releases all resources.
LLMs drop from 71.1% to 38.0% accuracy on medical questions when misleading context is injected, measured via new MedMisBench benchmark with 10,932 items.
Large-scale evaluation shows retrieval-augmented generation yields only marginal and inconsistent gains (1-2 points) over no-retrieval baselines in biomedical QA, with model choice dominating retriever or corpus effects.
AstroMind is a new physics-grounded benchmark for LLM reasoning on spacecraft behavior across intent inference, maneuver estimation, and threat assessment, evaluated on several open-weight models.
Evaluation of 6233 MedGPTs finds 25-30% with low factual accuracy, 33.6-54.3% violating operational thresholds, and 57% of action-enabled models lacking privacy disclosures.
PULSE demonstrates that agentic LLM-based investigation of passive smartphone sensing data achieves balanced accuracies of 0.743 (with diary) and 0.713 (sensing-only) for predicting emotion regulation desire and intervention availability in 50 cancer survivors.
Intent-aware retrieval over assertion-labeled knowledge graphs improves clinical QA accuracy by 22 percentage points on a new MIMIC-IV benchmark that stresses negation, temporality, and attribution.
CuraView detects sentence-level faithfulness hallucinations in medical discharge summaries via GraphRAG knowledge graphs and multi-agent evidence grading, achieving 0.831 F1 on critical contradictions with a fine-tuned Qwen3-14B model and 50% relative improvement over baselines.
HealthBench Professional is a physician-scored benchmark of real clinician-LLM chats showing GPT-5.4 outperforming other models and human physicians on clinical tasks.
The authors introduce Agentivism as a learning theory for human-AI interaction that explains how durable capability develops through selective delegation, epistemic monitoring, reconstructive internalization, and transfer under reduced support.
Health AI benchmarks exhibit a validity gap, with only 42% referencing objective data (mostly wellness wearables), rare complex inputs like labs or imaging, and minimal coverage of vulnerable groups or chronic care.
HyEm maps radius-controlled hyperbolic ontology embeddings to Euclidean space for ANN indexing and applies query-adaptive hyperbolic reranking to improve hierarchy-aware retrieval while preserving most Euclidean performance on flat queries.
FaithMed applies reinforcement learning with process-level rewards derived from evidence-based medicine rubrics to improve both task performance and reasoning faithfulness in medical LLMs.
LLM-powered conversational voice sleep diaries achieved higher adherence and richer contextual reports than text-based diaries, with a noted trade-off in structured field completeness.
A pre-response classifier predicts user rejection risk for clinical LLM outputs with AUROC 0.719 over 4.5 months of deployment data by incorporating deployment-specific context.
AIBuildAI-2 introduces a knowledge-enhanced agent with a hierarchical evolving external knowledge base that dynamically loads relevant AI development expertise, achieving first place on MLE-Bench at 70.7% medal rate.
Single-agent LLM frameworks outperform naive multi-agent systems in multimodal clinical risk prediction tasks and are better calibrated.
citing papers explorer
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MedHal-Loc: Are "Explainable-by-Architecture" Medical Hallucination Detectors Faithful Localizers? A Localization Benchmark
MedHal-Loc benchmark shows KG-triple hallucination detectors localize errors no better than chance on controlled medical statements due to entity extraction limits, while NLI and consistency methods succeed above chance, and real hallucinations are mostly diffuse conclusion changes.
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AutoMedBench: Towards Medical AutoResearch with Agentic AI Models
AutoMedBench evaluates AI agents on long-horizon medical workflows across five stages and finds validation and submission as dominant failure points based on thousands of runs.
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Hijacking Agent Memory: Stealthy Trojan Attacks Through Conversational Interaction
MemPoison enables stealthy memory poisoning in LLM agents via dialogue by using semantic relational bridges, entity masquerading, and joint embedding optimization to bypass selective extraction and rewriting, achieving up to 0.95 attack success rate.
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JMed48k: A Multi-Profession Japanese Medical Licensing Benchmark for Vision-Language Model Evaluation
JMed48k is a new benchmark of Japanese healthcare licensing exams used to evaluate 21 VLMs, with a paired image-removal audit revealing large differences in how models and professions benefit from visual content.
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Evaluating Patient Safety Risks in Generative AI: Development and Validation of a FMECA Framework for Generated Clinical Content
A novel FMECA-based framework was developed and validated for systematic assessment of patient safety risks in LLM-generated clinical discharge summaries, demonstrating moderate-to-substantial inter-rater agreement and good usability.
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A Multi-Analyst LLM Pipeline for Auditable Rule Discovery Across 68 Public Physiological Corpora
A controlled four-LLM analyst pipeline over 68 commercial-compatible physiological corpora produced 94 build-now detector components after deduplication, threshold audit, and native-channel/no-personalization gates.
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Cross-Lingual Exploration for Parametric Knowledge
Cross-lingual prompt exploration improves factual recall and consistency in LLMs across 17 languages more efficiently than native-language scaling.
-
MARD: Mirror-Augmented Reasoning Distillation for Mechanism-Level Drug-Drug Interaction Prediction
MARD-7B outperforms baselines and GPT-4o on novel drug pairs for mechanism-level DDI prediction via a new distillation pipeline with verifiable process rewards and releases all resources.
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Measuring Epistemic Resilience of LLMs Under Misleading Medical Context
LLMs drop from 71.1% to 38.0% accuracy on medical questions when misleading context is injected, measured via new MedMisBench benchmark with 10,932 items.
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When Retrieval Doesn't Help: A Large-Scale Study of Biomedical RAG
Large-scale evaluation shows retrieval-augmented generation yields only marginal and inconsistent gains (1-2 points) over no-retrieval baselines in biomedical QA, with model choice dominating retriever or corpus effects.
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AstroMind: A High-Fidelity Benchmark for Spacecraft Behavior Reasoning Based on Large Language Models
AstroMind is a new physics-grounded benchmark for LLM reasoning on spacecraft behavior across intent inference, maneuver estimation, and threat assessment, evaluated on several open-weight models.
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Do No Harm? Hallucination and Actor-Level Abuse in Web-Deployed Medical Large Language Models
Evaluation of 6233 MedGPTs finds 25-30% with low factual accuracy, 33.6-54.3% violating operational thresholds, and 57% of action-enabled models lacking privacy disclosures.
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PULSE: Agentic Investigation with Passive Sensing for Proactive Intervention in Cancer Survivorship
PULSE demonstrates that agentic LLM-based investigation of passive smartphone sensing data achieves balanced accuracies of 0.743 (with diary) and 0.713 (sensing-only) for predicting emotion regulation desire and intervention availability in 50 cancer survivors.
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ClinicalBench: Stress-Testing Assertion-Aware Retrieval for Cross-Admission Clinical QA on MIMIC-IV
Intent-aware retrieval over assertion-labeled knowledge graphs improves clinical QA accuracy by 22 percentage points on a new MIMIC-IV benchmark that stresses negation, temporality, and attribution.
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CuraView: A Multi-Agent Framework for Medical Hallucination Detection with GraphRAG-Enhanced Knowledge Verification
CuraView detects sentence-level faithfulness hallucinations in medical discharge summaries via GraphRAG knowledge graphs and multi-agent evidence grading, achieving 0.831 F1 on critical contradictions with a fine-tuned Qwen3-14B model and 50% relative improvement over baselines.
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HealthBench Professional: Evaluating Large Language Models on Real Clinician Chats
HealthBench Professional is a physician-scored benchmark of real clinician-LLM chats showing GPT-5.4 outperforming other models and human physicians on clinical tasks.
-
Agentivism: a learning theory for the age of artificial intelligence
The authors introduce Agentivism as a learning theory for human-AI interaction that explains how durable capability develops through selective delegation, epistemic monitoring, reconstructive internalization, and transfer under reduced support.
-
The Validity Gap in Health AI Evaluation: A Cross-Sectional Analysis of Benchmark Composition
Health AI benchmarks exhibit a validity gap, with only 42% referencing objective data (mostly wellness wearables), rare complex inputs like labs or imaging, and minimal coverage of vulnerable groups or chronic care.
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HyEm: Query-Adaptive Hyperbolic Retrieval for Biomedical Ontologies via Euclidean Vector Indexing
HyEm maps radius-controlled hyperbolic ontology embeddings to Euclidean space for ANN indexing and applies query-adaptive hyperbolic reranking to improve hierarchy-aware retrieval while preserving most Euclidean performance on flat queries.
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FaithMed: Training LLMs For Faithful Evidence-Based Medical Reasoning
FaithMed applies reinforcement learning with process-level rewards derived from evidence-based medicine rubrics to improve both task performance and reasoning faithfulness in medical LLMs.
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Better Adherence, Richer Context: A Field Evaluation of LLM-Powered Conversational Voice Diaries for Sleep
LLM-powered conversational voice sleep diaries achieved higher adherence and richer contextual reports than text-based diaries, with a noted trade-off in structured field completeness.
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Deployment-Centered Evaluation: Predicting Query-Level Rejection Risk in a Clinical LLM System
A pre-response classifier predicts user rejection risk for clinical LLM outputs with AUROC 0.719 over 4.5 months of deployment data by incorporating deployment-specific context.
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AIBuildAI-2: A Knowledge-Enhanced Agent for Automatically Building AI Models
AIBuildAI-2 introduces a knowledge-enhanced agent with a hierarchical evolving external knowledge base that dynamically loads relevant AI development expertise, achieving first place on MLE-Bench at 70.7% medal rate.
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AgentRx: A Benchmark Study of LLM Agents for Multimodal Clinical Prediction Tasks
Single-agent LLM frameworks outperform naive multi-agent systems in multimodal clinical risk prediction tasks and are better calibrated.
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Decodable but Not Corrected by Fixed Residual-Stream Linear Steering: Evidence from Medical LLM Failure Regimes
Overthinking in medical QA is linearly decodable at 71.6% accuracy yet fixed residual-stream steering yields no correction across 29 configurations, while enabling selective abstention with AUROC 0.610.
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MedFabric and EtHER: A Data-Centric Framework for Word-Level Fabrication Generation and Detection in Medical LLMs
MedFabric dataset and EtHER detector achieve over 15% better word-level fabrication detection in medical LLMs than prior methods by generating stylistically faithful errors and using decomposition-based checking.
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Measuring Competency, Not Performance: Item-Aware Evaluation Across Medical Benchmarks
MedIRT applies Item Response Theory to medical LLM benchmarks to separate latent competency from item difficulty and discrimination, producing more stable rankings and revealing domain heterogeneity than accuracy alone.
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Infherno: End-to-end Agent-based FHIR Resource Synthesis from Free-form Clinical Notes
Infherno deploys LLM agents with code execution and terminology tools to synthesize FHIR resources from unstructured clinical notes, matching human baseline performance on synthetic and real datasets.
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Deep Learning for Semen Analysis in Male Infertility: Computer Vision, Multimodal Fusion, and Clinical Translation
A comprehensive review synthesizing AI-driven sperm analysis across computer vision tasks, multimodal fusion, and a staged clinical translation roadmap.
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What the LLM Should Not Say: Boundary-Aware Context Grounding for A Seven-Channel EEG Agent
NeuraDock Agent is an open-source architecture that pairs a local EEG engine with a restricted LLM context pack to enforce hardware and implementation boundaries for seven-channel recordings.
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MedRLM: Recursive Multimodal Health Intelligence for Long-Context Clinical Reasoning, Sensor-Guided Screening, Evidence-Grounded Decision Support, and Community-to-Tertiary Referral Optimization
Proposes MedRLM, a recursive agent-based multimodal framework for long-context clinical reasoning, sensor-guided screening, and referral optimization using a Clinical Evidence Graph Memory.
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UniReason-Med: A Shared Grounded Reasoning Interface for 2D-to-3D Transfer in Medical VQA
UniReason-Med introduces a unified framework for 2D and 3D medical VQA with shared grounded reasoning, trained on a 220K dataset, claiming that joint 2D+3D supervision improves 3D performance over 3D-only training.
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Afrispeech Semantics: Evaluating Audio Semantic Reasoning in Spoken Language Models Across Domains and Accents
Audio language models are benchmarked on five semantic and paralinguistic reasoning tasks to reveal limitations in handling spoken audio evidence, accent variation, and domain shifts.
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Medical Incident Causal Factors and Preventive Measures Generation Using Tag-based Example Selection in Few-shot Learning
Tag-based few-shot selection yields higher precision and stability than random or similarity-based methods when using LLMs to analyze medical incidents.
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Research on Security Enhancement Methods for Adversarial Robust Large Language Model Intelligent Agents for Medical Decision-Making Tasks
ARSM-Agent cuts attack success rate to 8.7% and reaches 0.91 knowledge consistency in medical tasks by linking risk perception, evidence retrieval, consistency verification, and confidence reweighting.
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Benchmarked Yet Not Measured -- Generative AI Should be Evaluated Against Real-World Utility
Generative AI evaluation must shift from static benchmark scores to measuring sustained improvements in human capabilities within specific deployment contexts.
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SchemaRAG: Dynamic Large Schema Reduction for LLM-driven Structured Information Extraction
SchemaRAG dynamically reduces large schemas via RAG for LLM information extraction, reporting up to 8.8% micro-F1 gain, 47% latency cut, and 48% token cost reduction on healthcare and e-commerce data.
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Toward Zero-Egress Psychiatric AI: On-Device LLM Deployment for Privacy-Preserving Mental Health Decision Support
A cross-platform mobile application deploys an ensemble of quantized open-source LLMs for fully local, DSM-5-aligned psychiatric decision support with claimed accuracy comparable to prior cloud versions.
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ClinQueryAgent: A Conversational Agent for Population Health Management
The paper introduces ClinQueryAgent, a conversational agent that converts natural language queries into database queries for population health management while keeping patient data secure, and reports its use by 128 staff across 15 NHS practices covering 148,319 patients.
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Benchmark Data Contamination of Large Language Models: A Survey
A survey reviewing benchmark data contamination in LLMs, its impact on evaluation, and alternative assessment approaches.
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A Hybrid Retrieval and Reranking Framework for Evidence-Grounded Retrieval-Augmented Generation
A hybrid RAG system with retrieval, Cohere reranking, and claim-level LLM judgment achieves 100% grounding accuracy on 200 claims from 25 biomedical queries in a pilot study.